What’s the Future of Gene Editing?
16th June 2026
In the first episode of the new season of ‘The Joy of Why,’ Nobel Laureate Jennifer Doudna discusses how she discovered CRISPR’s genome-editing power, the breakthroughs and hurdles during its explosive growth, and what lies ahead for this groundbreaking technology.
One of the most surprising and remarkable discoveries in recent scientific history has been CRISPR. Short for Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR is a form of immune system that evolved in bacteria more than a billion years ago to defend against persistent viral threats. Under attack, bacteria can snip a small fragment of a virus’s DNA, store it in the CRISPR region of their genome, and then use it to recognize and destroy the same virus if it returns. The CRISPR-Cas9 system, to give it its longer name, consists of a short strand of guide RNA that identifies where to cut the DNA and a protein that acts as the molecular scissors.
What made this system truly revolutionary was the demonstration in 2012 that it could be reprogrammed with different pieces of guide RNA to edit virtually any genome in any species, and at a level of precision and ease that far surpassed existing gene-editing tools. Since then, the editing capability of CRISPR has been tested on everything from developing disease treatments to engineering drought-resistant crops to resurrecting genes of extinct species. The possibilities have expanded so rapidly that researchers, ethicists, and regulators have found themselves struggling to keep up.
God forbid that ‘ethicists’ (professional tellers of other people what to do) and regulators (professional tellers of other people what not to do) find themselves ‘struggling to keep up’.