Scientists Discover a Protein That Reverses Cellular Aging
4th March 2025
In their quest for answers, researchers pinpointed a specific protein, AP2A1 (Adaptor Protein Complex 2, Alpha 1 Subunit), which seems crucial to this cellular phenomenon.
Found predominantly in senescent cells, particularly within the structural stress fibers, AP2A1 could be the key to understanding cellular aging.
To explore AP2A1’s function, researchers manipulated its presence in cells, observing significant effects.
“The results were very intriguing,” said Shinji Deguchi, senior author of the study. “Suppressing AP2A1 in older cells reversed senescence and promoted cellular rejuvenation, while AP2A1 overexpression in young cells advanced senescence.”