Human Achievement of the Day: Using HIV to Cure Leukemia
8th March 2013
Read it. And watch the video.
Pediatric oncologist Stephan A. Grupp of CHOP and his colleagues presented the updated results of their clinical trial of the innovative therapy at the American Society of Hematology (ASH) annual meeting on December 10 in Atlanta. To conduct the treatment (officially called CTL019), doctors collect T-cells from the patient and reengineer them with a disabled form of HIV to recognize and attach to a protein that is found only on the surface of B-cells. B-cells are found in the immune system and become cancerous in certain leukemias and lymphomas. Once the reengineered T-cells are injected into the patient, they multiply and are able to attach to the cancerous B-cells—which would otherwise fly under the immune system’s radar—and destroy them.