World-First Therapy Using Donor Cells Sends Autoimmune Diseases Into Remission
5th October 2024
One woman and two men with severe autoimmune conditions have gone into remission after being treated with bioengineered and CRISPR-modified immune cells1. The three individuals from China are the first people with autoimmune disorders to be treated with engineered immune cells created from donor cells, rather than ones collected from their own bodies. This advance is the first step towards mass production of such therapies.
One of the recipients, Mr Gong, a 57-year-old man from Shanghai, has systemic sclerosis, which affects connective tissue and can result in skin stiffening and organ damage. He says that three days after receiving the therapy, he felt his skin loosen and he could start moving his fingers and opening his mouth again. Two weeks later, he returned to his office job. “I feel very good,” he says, more than a year after receiving the treatment.
Engineered immune cells, called chimeric antigen receptor (CAR) T cells, have shown great promise in treating blood cancers — half a dozen products are approved in the United States — and potential for treating autoimmune conditions such as lupus and multiple sclerosis, in which rogue immune cells release autoantibodies that attack the body’s own tissue. But the therapy typically relies on a person’s own immune cells, and this personalization makes it expensive and time consuming.